Advance Directives in the Autonomous Region of Madrid are in keeping with legislation at national level (refer to the report on advance directives in Spain).

The Autonomous Region of Madrid has developed its own legislation with regards to healthcare directives. In 2001, Madrid passed Ley 12/2001, de 21 de diciembre, de Ordenación Sanitaria de la Comunidad de Madrid (Law 12/2001 of December 21st, concerning Health Regulation in the Autonomous Region of Madrid) , which, in article 28, addresses healthcare directives.

In 2005, Madrid passed Ley 3/2005, de 23 de mayo, por la que se regula el ejercicio del derecho a formular instrucciones previas en el ámbito sanitario y se crea el registro correspondiente (Law 3/2005 of May 23rd, for the regulation of the exercise of the right to draw up healthcare directives within the health sector and the creation of the corresponding registry).

Subsequently, Madrid passed Decreto 101/2006, de 16 de noviembre, del Consejo de Gobierno, por el que se regula el Registro de Instrucciones Previas de la Comunidad de Madrid (Decree 101/2006 of November 16th, issued by the Governing Council, fir the regulation of the Healthcare Directives Registry of the Autonomous Region of Madrid)

One month later, Madrid passed Orden 2191/2006 de 18 de diciembre, por la que se desarrolla el Decreto 101/2006 y se establecen los modelos oficiales de los documentos de solicitud de inscripción de las instrucciones previas y de su revocación, modificación o sustitución (Order 2191/2006 of December 18th, for the implementation of Decree 101/2006 and the drawing up of official models of the documents to request registration of healthcare directives and revoke, modify or substitute such directives).

Finally, in 2007, Madrid passed Orden 645/2007, de 19 de abril, del Consejero de Sanidad y Consumo, por la que se regula el otorgamiento de las Instrucciones Previas, su modificación, sustitución y revocación ante el personal al servicio de la Administración (Order 645/2007, of April 19th, issued by the Department for Health and Consumer Affairs, for the regulation of the execution of Healthcare Directives and their modification, substitution and revocation before the personnel in the employ of the Administration).